Stanford Immunology

Faculty

Stanford Immunology currently includes 70 faculty members from many departments/divisions. 

Faculty Asilomr 2013

Asilomar Retreat 2013 - Immunology Faculty

Biochemistry
Biological Sciences
Computer Science
Developmental Biology
Genetics
Infectious Diseases & Geographic Medicine
Microbiology & Immunology
Molecular & Cellular Physiology
Neurology & Neurosciences
Neurosurgery
Otolaryngology
Pathology
Psychiatry & Behavioral Sciences
Structural biology
Surgery
Urology
Department of Medicine/Divisions:
Blood & Bone Marrow Transplant
Cardiovascular Medicine
Gastroenterology &Hepatology
Hematology
Oncology
Immunology & Rheumatology
Infectious Diseases
Radiology
Department of Pediatrics/Dvisions:
Human Gene Therapy
Immunology & Allergy
Infectious Diseases
Neonatology
Systems Medicine

Program Faculty

Stanford Immunology's faculty members have a broad spectrum of expertise and represent some of the most outstanding scientists in their respective areas. The research interests of our faculty cover the major areas of modern immunology including cellular, molecular, clinical, and structural immunology, and many aspects of the function of the immune system in each of these areas. Research includes studies of the development and function of T- and B- lymphocytes, natural killer cells, regulatory T-cells, macrophages, dendritic cells, and the specific tissues and organs that contribute to host defenses.  The program has a strong molecular component and many of the laboratories have focused on key molecules in the induction and expression of immune responsiveness.  These include the molecules encoded by the major histocompatability complex, T-cell receptors, immunoglobulins, costimulatory and accessory molecules, adhesion molecules including selectins and integrins, and chemoattractant receptors.  Studies in progress range from analysis of gene expression using microarrays and robotic sequencers, to studies of evolution, to protein biochechemistry, large scale antibody microarrays and the 3-dimensional structure of a number of important proteins by protein crystallography.  A number of faculty are focusing on the cellular interactions that are characteristic of lymphocytes, from the architecture of the “immunological synapses” that they form to the specific molecular interactions and signaling cascades that accompany activation, beginning with their characteristic cell surface receptors, intracellular signal transduction molecules, and transcription factors regulating gene expression in immune cells.  Another major strength of the program is the wealth of new tools and technologies available to immunologists that are well supported here by key laboratories and core facilities in the Immunology program.  These include confocal microscopy for cell imaging, cDNA microarrays of both mouse and human genes for gene expression profiling, large scale microarrays of antibodies to proteins, lipids and carbohydrates, and transgenic core facilities, as well as the availability of a large reservoir of transgenic and knock-out mouse strains for use in all of these studies. 

A number of our faculty also focus on the applications of these basic findings to clinical diseases, ranging from type I diabetes mellitus, multiple sclerosis, and rheumatoid arthritis to a number of infectious diseases, allergy and several types of cancer.  Immune-derived cells and factors that participate in the regulation of immunologic and non-immunologic processes with direct relevance to disease are studied.  In many of these diseases, mechanisms of self-tolerance fail and the immune system begins to react against itself as autoimmunity, or fails to react adequately against new proteins expressed in cancer cells.  Array methodologies for autoantibody detection in autoimmune patients and for functional T-cell profiling in vaccine studies have also been pioneered at Stanford.  The Human Immune Monitoring Center (HIMC) is a new facility, led by Holden Maecker, Director, was jointly developed by the Institute of Immunology, Transplantation and Infectious Disease (Mark Davis, ITI) and the Center of Clinical Immunology at Stanford (C. Garrison Fathman, CCIS). The laboratory is charged with developing and implementing assays that will monitor the health of the human immune system and to make these assays available to the Stanford Medical research community and others, as resources permit. 

The Great Gulf

The Great Gulf

Courtesy of G.R. Crabtree

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